Hepatitis
19 May 2012
Market Research Report – Hepatitis Therapy Area Pipeline Report
Hepatitis Therapy Area Pipeline Report contains detailed information on the hepatitis drug pipeline. This report provides insight into the pipeline status of hepatitis drugs by company and by stage as well as a summary of the latest news and developments in this area.
Scope of the report:
Each Life Science Analytics’ Therapy Area Pipeline Report provides the user with real detail on drug pipelines, by company and by stage, for each specific therapy area. The latest news, by company, also ensures that each report is fresh and up-to-date.
In addition to new developments and disease specific pipeline projects, each report also contains extensive information in tabular format on a company’s full product pipeline and products by phase of development with regard to the therapy area.
Full pipeline details, by stage, are provided and include detailed product descriptions, information on partnering activity plus clinical trial intelligence. Each Therapy Area Pipeline Report also provides detail on the top 20 companies with products in the early stage of development and the top 20 companies with products in the late stage of development. Finally, each report also provides a comparison with other major indications in the disease hub based on Marketed Products vs. Pipeline Products.
Key benefits
• Understand a company’s strategic position by accessing detailed independent intelligence on its product pipeline for specific therapy areas.
• Keep track of your competitors and partners by better understanding their product pipeline.
• Monitor a company’s research effectiveness by determining pipeline depth and number of products in development by clinical phase for specific disease areas.
• Maintain a critical competitive advantage.
Table of Contents :
” “% of Products by Phase of Development
No. of Products by Phase of Development
Marketed Products vs. Pipeline Products
Company Overview – Pipeline Projects
Legend
–Top 5 Companies in Early Stage Hepatitis Products
–Top 5 Companies in Late Stage Hepatitis Products
–Top 5 Companies in Marketed Hepatitis Products
Patent Expirations
Upcoming Milestones
Product Sales
Full Pipeline View
–Product Details : Unknown/Research
–Product Details : Pre Clinical
–Product Details : Phase I
–Product Details : Phase II
–Product Details : Pending Approval
–Product Details : On the Market
For more information please visit :
http://www.aarkstore.com/reports/Hepatitis-Therapy-Area-Pipeline-Report-66780.html
From: Aarkstore Enterprise
Contact: Anna
Ph.No.91927282585
Email: winaarkstore@gmail.com
URL:http://www.aarkstore.com/
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(-)-Epigallocatechin-3-gallate, found in the green tea extract, in a novel Hsp90 inhibitor. $49.99 Numerous animal studies have shown that epigallocatechin-3-gallate (EGCG), a major component of green tea, protects against certain types of cancers, although the mechanism has not yet been determined. Our laboratory previously demonstrated that EGCG blocks aryl hydrocarbon receptor (AhR)-mediated transcription induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Unlike other AhR antagonists that directly bind to the AhR, EGCG inhibits AhR-mediated transcription by binding to hsp90. I hypothesize that EGCG exerts anti-AhR and anti-cancer effects by acting as an hsp90 inhibitor. Using proteolytic footprinting, immunoprecipitation and an ATP-agarose pull-down assay, I determined that EGCG directly modulates the conformation of hsp90 and binds at or near to the C-terminal ATP binding site of hsp90. Direct binding of 3H-EGCG to purified human hsp90 was observed by competitive binding assay suggesting a Kd of ~780nM. Novobiocin (a C-terminal hsp90 inhibitor) and ATP compete with 3H-EGCG for binding to hsp90. Hsp90 chaperone function, as demonstrated by the ability to mediate refolding of denatured luciferase, is inhibited by EGCG treatment. Hsp90 dimerization, which occurs at the C-terminal end, is also inhibited by EGCG treatment. EGCG also modified the association of hsp90 with several cochaperones. Co-immunoprecipitation studies show that EGCG stabilizes an AhR complex that includes hsp90 and XAP2 (hepatitis B virus X-associated protein 2), and decreases the association of aryl hydrocarbon nuclear translocator (Arnt) to ligand-activated AhR. Thus, EGCG, through its ability to bind to hsp90, decreases the association of AhR, an hsp90 client protein, with Arnt and blocks AhR response element (AhRE) recognition. These studies indicate a novel mechanism whereby EGCG inhibits ligand-induced AhRE binding and AhR-mediated transcriptional activity by acting as an hsp90 inhibitor. In EGCG-treated human ovarian carcinoma SKOV3 cells, decreased levels of several |
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(-)-Epigallocatechin-3-gallate, found in the green tea extract, in a novel Hsp90 inhibitor. $49.99 Numerous animal studies have shown that epigallocatechin-3-gallate (EGCG), a major component of green tea, protects against certain types of cancers, although the mechanism has not yet been determined. Our laboratory previously demonstrated that EGCG blocks aryl hydrocarbon receptor (AhR)-mediated transcription induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Unlike other AhR antagonists that directly bind to the AhR, EGCG inhibits AhR-mediated transcription by binding to hsp90. I hypothesize that EGCG exerts anti-AhR and anti-cancer effects by acting as an hsp90 inhibitor. Using proteolytic footprinting, immunoprecipitation and an ATP-agarose pull-down assay, I determined that EGCG directly modulates the conformation of hsp90 and binds at or near to the C-terminal ATP binding site of hsp90. Direct binding of 3H-EGCG to purified human hsp90 was observed by competitive binding assay suggesting a Kd of ~780nM. Novobiocin (a C-terminal hsp90 inhibitor) and ATP compete with 3H-EGCG for binding to hsp90. Hsp90 chaperone function, as demonstrated by the ability to mediate refolding of denatured luciferase, is inhibited by EGCG treatment. Hsp90 dimerization, which occurs at the C-terminal end, is also inhibited by EGCG treatment. EGCG also modified the association of hsp90 with several cochaperones. Co-immunoprecipitation studies show that EGCG stabilizes an AhR complex that includes hsp90 and XAP2 (hepatitis B virus X-associated protein 2), and decreases the association of aryl hydrocarbon nuclear translocator (Arnt) to ligand-activated AhR. Thus, EGCG, through its ability to bind to hsp90, decreases the association of AhR, an hsp90 client protein, with Arnt and blocks AhR response element (AhRE) recognition. These studies indicate a novel mechanism whereby EGCG inhibits ligand-induced AhRE binding and AhR-mediated transcriptional activity by acting as an hsp90 inhibitor. In EGCG-treated human ovarian carcinoma SKOV3 cells, decreased levels of several |
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100 Questions & Answers About Hepatitis C $23.95 There are approximately 2.5 million cases of Hepatitis C in the United States and approximately 200 million worldwide. Whether you”re a newly diagnosed patient, a friend or relative of someone with Hepatitis C, this book offers help. Written by two physicians from Lahey Clinic Medical Center, Dr. Fabry and Dr. Narasimhan, this book provides authoritative, practical answers to the most common questions about Hepatitis C. |
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100 Questions & Answers about Hepatitis C: A Lahey Clinic Guide $13.23 New – There are approximately 2.5 million cases of Hepatitis C in the United States and approximately 200 million worldwide. Whether you’re a newly diagnosed patient, a friend or relative of someone with Hepatitis C, this book offers help. Written by two physicians from Lahey Clinic Medical Center, Dr. Fabry and Dr. Narasimhan, this book provides authoritative, practical answers to the most common questions about Hepatitis C. |
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20 Common Problems in Gastroenterology $62 20 Common Problems in Gastroenterology gives you practical, useful ways to help treat patients diagnosed with commonly encountered problems in gastroenterologyFeatures:• Best available evidence-based, solutions-oriented guide to the GI conditions you encounter daily• Clear, concise, and up-to-date recommendations on testing, diagnostics, medications, and dosing, including costs • Useful answers on heartburn, GERD, and chest pain Quick and essential answers on issues of chronic and acute abdominal pain• Help with cases of bleeding in the upper and lower GI tract• What you need to know about occult bleeding and iron deficiency anemia• Effective advice and treatments for the common complaint of flatulence• Expert guidance on diagnosing and treating rectal pain and anorectal disease• Clear direction and useful approaches to nausea, vomiting, dysphagia, dyspepsia, weight loss, and acute diarrhea in adults• Effective care for patients with viral hepatitis, liver masses, abnormal liver function tests, and biliary obstructions• Realistic guidelines for helping with functional gastrointestinal disorders• What every clinician needs to know about managing chronic gastroenterological problemsOther titles in the 20 Common Problems series include Behavioral Health, Dermatology, End of Life, Ethics, Geriatrics, Pediatrics, Preventive Health, Primary Care, Surgical Problems ; Procedures, Urology, and Women’s Health Care. |
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2000s Medical Outbreaks $19.99 Purchase includes free access to book updates online and a free trial membership in the publisher’s book club where you can select from more than a million books without charge. Chapters: 2009 Flu Pandemic, 2008-2009 Zimbabwean Cholera Outbreak, 2007 Australian Equine Influenza Outbreak, 2006 North American E. Coli Outbreak, 2008 United States Salmonellosis Outbreak, Progress of the Sars Outbreak, 2001 United Kingdom Foot-And-Mouth Crisis, 2007 United Kingdom Foot-And-Mouth Outbreak, 2005 Dengue Outbreak in Singapore, Mumps Outbreaks in the 2000s, 2007 Bernard Matthews H5n1 Outbreak, Measles Outbreaks in the 2000s, Chikungunya Outbreaks, 2008 Canadian Listeriosis Outbreak, 2009-2010 West African Meningitis Outbreak, 2009 Gujarat Hepatitis Outbreak, 2006 Dengue Outbreak in India, Bcg Disease Outbreak in Finland in the 2000′s, 2009 Bolivian Dengue Fever Epidemic, 2007 Central Luzon Hog Cholera Outbreak, 2002 Barrow-In-Furness Legionnaires’ Disease Outbreak, 2008 H5n1 Outbreak in West Bengal, 2007 Iraq Cholera Outbreak, 2006 Dengue Outbreak in Pakistan, 2008 Democratic Republic of the Congo Cholera Outbreak. Excerpt: The outbreak of foot-and-mouth disease in the United Kingdom in 2001 caused a crisis in British agriculture and tourism . This epizootic saw 2,000 cases of the disease in farms in most of the British countryside. Over 10 million sheep and cattle were killed in an eventually successful attempt to halt the disease. Cumbria was the worst affected area of the country, with 843 cases. With the intention of controlling the spread of the disease, public rights of way across land were closed by order. This damaged the popularity of the Lake District as a tourist destination. By the time the disease was halted by October 2001, the crisis was estimated to have cost the United Kingdom £8bn ( $16bn).Background The UK’s last outbreak had been in 1967, and had been confined to a small area of the country. Since then there had been changes in farming |
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2009 Conquering Hepatitis-the Empowered Patient’s Complete Reference-Diagnosis, Treatment Options, Prognosis (Two Cd-Rom Set) $54.95 New |
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2009 Conquering Hepatitis-the Empowered Patient’s Complete Reference-Diagnosis, Treatment Options, Prognosis (Two Cd-Rom Set) $55.95 New |
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2009 in India, Including: Bollywood Films of 2009, Kannada Films of 2009, 2009 Mangalore Pub Attack, 2009 Orissa Train Derailment, 2009 Gujarat Hepatitis Outbreak, Bomai Killing, 2009, Khaigam Killing, 2009, Risat-2, 2009 Tamil Diaspora Protests $19.19 Used – Events in the year 2009 in the Republic of India. * Prime Minister of India – Manmohan Singh * January 1 – 2009 Guwahati bombings: Five persons, including a boy and a woman, were killed and about 50 injured in serial bomb blasts in Guwahati, Assam. * January 2 – Indian Government in tandem with the Reserve Bank of India (RBI) announces the much-awaited second Stimulus Package aimed at reversing the economic slowdown. * January 4 – All-India Motor Transport Congress (AIMTC) has decided to |
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2009 in India: 2009 Shopian Rape and Murder Case, Operation Lalgarh, Tamil Films of 2009, Bomai Killing, 2009, Bollywood Films of 2009 $16.97 New – Chapters: 2009 Shopian Rape and Murder Case, Operation Lalgarh, Tamil Films of 2009, Bomai Killing, 2009, Bollywood Films of 2009, 2009 Mangalore Pub Attack, 2009 Tamil Diaspora Protests, 2009 Union Budget of India, 2009 Flu Pandemic in India, Khaigam Killing, 2009, Baramulla Killing, June 2009, Naz Foundation V. Govt. of Nct of Delhi, Kannada Films of 2009, 2009 Gujarat Hepatitis Outbreak, Agropedia, Risat-2, 2009 Gujarat Hooch Tragedy, Air India Flight 829, Kingfisher Airlines Flight 412 |
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2009 in India: 2009 Shopian Rape and Murder Case, Operation Lalgarh, Tamil Films of 2009, Bomai Killing, 2009, Bollywood Films of 2009 $16.97 Used – Chapters: 2009 Shopian Rape and Murder Case, Operation Lalgarh, Tamil Films of 2009, Bomai Killing, 2009, Bollywood Films of 2009, 2009 Mangalore Pub Attack, 2009 Tamil Diaspora Protests, 2009 Union Budget of India, 2009 Flu Pandemic in India, Khaigam Killing, 2009, Baramulla Killing, June 2009, Naz Foundation V. Govt. of Nct of Delhi, Kannada Films of 2009, 2009 Gujarat Hepatitis Outbreak, Agropedia, Risat-2, 2009 Gujarat Hooch Tragedy, Air India Flight 829, Kingfisher Airlines Flight 41 |
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Categories: Hepatitis | Tagged: hepatitis, hepatitis b, hepatitis b vaccine, hepatitis c, hepatitis c symptoms |